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Общество клинической адаптологии и медицинской иммунологии
Объединение экспертов в области клинической иммунологии и аллергологии
Общество клинической адаптологии
и медицинской иммунологии
и медицинской иммунологии
Объединение экспертов в области клинической иммунологии и аллергологии
Role of the Extracellular Traps in Central Nervous System
Xinyan Wu, Hanhai Zeng, Lingxin Cai and Gao Chen
Department of Neurological Surgery The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Department of Neurological Surgery The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Role of the Extracellular Traps in Central Nervous SystemIt has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, eosinophils, and mast cells. With the development of research related to central nervous system, the role of ETs has been valued in neuroinflammation, blood–brain barrier, and other fields. Meanwhile, it has been found that microglial cells as the resident immune cells of the central nervous system can also release ETs, updating the original understanding. This review aims to clarify the role of the ETs in the central nervous system, especially in neuroinflammation and blood– brain barrier.
Keywords: extracellular traps, neuroinflammation, blood–brain barrier (BBB), stroke, neurodegenaration, CNS
Keywords: extracellular traps, neuroinflammation, blood–brain barrier (BBB), stroke, neurodegenaration, CNS
